OTHER
Therapeutics
Review: rivastigmine reduces rate of cognitive decline and improves performance in mild to moderate Alzheimer’s
| The first 150 words of the full text of this article appear below. |
Is rivastigmine effective for the treatment of Alzheimer’s disease?
Cognitive function (measured by psychometric tests); dependency; global impression; functional performance; behavioural disturbance; quality of life; rates of institutionalisation; effect on carer; acceptability of treatment as measured by withdrawal from trials; adverse effects; death.
Systematic review with meta-analysis.
The Specialised Register of the Cochrane Dementia and Cognitive Improvement Group (searched from date of inception to December 2005). The Cochrane Library, MEDLINE, PsycINFO, EMBASE, CINAHL and LILACS were searched for records added after December 2005 to March 2008; ongoing and other unpublished trials searched through Novartis, FDA, EMEA, NICE, Google and Copernic websites.
Randomised, double blind, placebo controlled trials of rivastigmine administered to patients with Alzheimer’s disease or probable Alzheimer’s disease (fulfilling DSM-IV or NINCDS-ADRDA) for more than 2 weeks. Exclusions: non-randomised trials; no allocation concealment. A single reviewer selected studies and assessed the quality of included trials on the basis
Aurus IEPE-Institute of Research and Education on Ageing, Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, Brazil
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