OTHER
Therapeutics
In adolescents with SSRI resistant depression, CBT/combined treatment is most effective in those with comorbid disorders
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What are the predictors and moderators of treatment response among adolescents with selective serotonin reuptake inhibitor (SSRI) resistant depression?
334 adolescents (aged 12–18 years) with a primary diagnosis of major depressive disorder in active treatment but who had not responded to a 2 month trial with an SSRI. See online notes for main exclusions.
US academic and community clinics; 2000–2006.
One of four 12 week regimens: switch to a second, different SSRI (paroxetine, fluoxetine or citalopram at 20–40 mg daily); switch to venlafaxine (150–225 mg daily); switch to second SSRI plus CBT; switch to venlafaxine plus CBT. Before the switch, participants’ existing medication was tapered to discontinuation over up to 2 weeks. CBT was delivered by experienced therapists with at least master’s level qualifications; up to 12 sessions of CBT (60–90 min each) were provided during the first 12 weeks (3–6 of them were family sessions). Predictor and moderator
University of Cambridge, Cambridge, UK
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Attention-deficit hyperactivity disorder
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