OTHER
Therapeutics
Review: clinically important differences between antidepressants
| The first 150 words of the full text of this article appear below. |
What are the effects of the 12 most commonly prescribed new generation antidepressants for moderate to severe major depression in adults?
Response to treatment at 8 weeks, defined as the proportion of patients having a 50% or greater reduction from baseline in Hamilton Depression Rating Scale or Montgomery–Asberg depression rating scale or those scoring "much improved" or "very much improved" on the clinical global impression; discontinuation as a measure of acceptability of treatment defined as the number of patients who terminated the study early for any reason during the first 8 weeks of treatment.
Systematic review with meta-analysis (pairwise with random effects model and mixed treatment meta-analysis).
Cochrane Collaboration Depression, Anxiety and Neurosis Controlled Trials registers (searched November 2007).
Randomised controlled trials comparing any of the following new generation antidepressants being used as monotherapy to treat adults with unipolar major depression: duloxetine, velanfaxine, sertraline, bupropion, citalopram, escitalopram, fluoxetine, minacipran,
Newcastle University, Newcastle upon Tyne, UK
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