THERAPEUTICS
Review: high frequency repetitive transcranial magnetic stimulation improves symptoms of major depression
| The first 150 words of the full text of this article appear below. |
What is the clinical efficacy of high frequency repetitive transcranial magnetic stimulation in people with major depression?
Depressive symptoms measured using the Hamilton Depression Rating Scale (HAMD) or the Montgomery–Asberg Depression Rating Scale (MADRS).
Design: Systematic review with meta-analysis.
Data sources: PubMed and Web of Science were searched from January 1980 to November 2007 for randomised controlled trials (RCTs). Reference lists of six previous meta-analyses and six reviews were hand searched.
Study selection and analysis:
English language studies from peer reviewed journals were appraised, and RCTs in adults with major depressive episodes without psychotic features (DSM-IV) that met the following criteria were selected: random allocation, double blind, sham controlled, parallel design, intention to treat analysis, minimum of five treatment sessions of high frequency (>5 Hz) repetitive transcranial magnetic stimulation (rTMS) over the left dorsolateral prefrontal cortex with an intensity >80% motor threshold (MT) and treatment sessions completed up to 6
Department of Psychiatry, Trinity College Dublin, St Patrick's Hospital, Dublin, Ireland
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