THERAPEUTICS
Rivastigmine three times daily improves cognition and response in Alzheimer’s disease
| The first 150 words of the full text of this article appear below. |
Feldman HH, Lane R. Rivastigmine: a placebo–controlled trial of BID and TID regimens in patients with Alzheimer’s disease. J Neurol Neurosurg Psychiatry 2007 Mar 12; [Epub ahead of print].
Design:
Randomised controlled trial.
Allocation:
Unclear.
Blinding:
Double blinded.
Follow-up period:
Twenty six weeks (treatment period only).
Setting:
Thirty seven research centres, Australia, Canada, Ireland, Italy, South Africa, and the UK; time period not stated.
Patients:
678 community dwelling adults aged 
50 years with Alzheimer’s disease (AD; meeting both DSM-IV criteria and criteria for "probable" Alzheimer’s disease of the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s disease and Related Disorders Association), and who had a Mini-Mental State Examination score of 10–26. Exclusions: severe obstructive pulmonary disease, cardiac disease, or other life threatening condition; use of anticholinergic drugs, insulin, psychotropics (with some exceptions), supplements containing acetylcholine precursors, or supposed memory enhancers.
Intervention:
Rivastigmine either twice (BID) or
Indiana University School of Medicine, Indianapolis, IN 46202, USA
Correspondence to:
Dr Howard Feldman, S192–2211 Westbrook Mall, Division of Neurology, Department of Medicine, University of British Columbia Hospital, Vancouver, BC, Canada, V6T 2B5
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Neurology
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Dementia, Alzheimer's type
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Psychiatry of old age
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Epidemiology
- Clinical trials (epidemiology)
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