Therapeutics
Cognitive behavioural therapy increases response in people with hypochondriasis
Greeven A, van Balkom AJLM, Visser S, et al. Cognitive behavior therapy and paroxetine in the treatment of hypochondriasis: a randomized controlled trial. Am J Psychiatry 2007;164:91–9.
Q Are cognitive behavioural therapy and paroxetine more effective than placebo for hypochondriasis?
| The first 150 words of the full text of this article appear below. |
Design:Randomised controlled trial.
Allocation:Concealed.
Blinding:Double blind (paroxetine and pill placebo groups only, blinding for cognitive behavioural therapy (CBT) group not described).
Follow-up period:Sixteen weeks.
Setting:Three psychiatric outpatient units in the Netherlands; January 1998 to July 2002.
Patients:112 adults (aged over 18 years) with hypochondriasis (DSM-IV). Main exclusions: severe comorbidity; substance abuse; diagnosis of anxiety or depression; use of antidepressants, antipsychotics or anticoagulants; already receiving psychotherapy; pregnancy or breastfeeding.
Intervention:CBT (6–16 individual sessions as needed), paroxetine (up to 60 mg daily), or pill placebo for 16 weeks.
Outcomes:Symptoms of hypochondriasis (4-point Likert scale version of the Whiteley Index); response (Jacobson and Truax criteria).
Patient follow-up:73% completed treatment (75% of CBT group; 70% of paroxetine group; 74% of placebo group); 97% included in last observation carried forward analyses.
Pooling results for CBT and paroxetine showed significantly improved symptoms compared with placebo (mean change from baseline in Whiteley Index score: –4.67, 95% CI –7.20 to
University of Southern Mississippi, Hattiesburg, MS, USA
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
-
Hypochondriasis
-
Epidemiology
-
Clinical trials (epidemiology)
-
Cagnitive behavioural psychotherapy
-
Substance dependence
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
