Therapeutics
Methylphenidate may improve symptoms but does not increase response compared with placebo in preschool children with ADHD
Greenhill L, Kollins S, Abikoff H, et al. Efficacy and safety of immediate-release methylphenidate treatment for preschoolers with ADHD. J Am Acad Child Adolesc Psychiatry 2006;45:1284–93.[CrossRef][Medline]
Q Is methylphenidate effective for preschool children with attention deficit/hyperactivity disorder?
| The first 150 words of the full text of this article appear below. |
Design:
Crossover randomised controlled trial (titration phase) followed by parallel group randomised controlled trial (efficacy phase).
Allocation:
Concealed.
Blinding:
Double blind.
Follow-up period:
Five weeks for titration phase and 4 weeks for efficacy phase.
Setting:
Six academic sites, USA; enrolment February 2001 to April 2003.
Patients:
Titration phase: 165 children aged 3–5.5 years with DSM-IV attention deficit/hyperactivity disorder (ADHD) of the predominantly hyperactive or combined subtypes (Revised Conners Parent and Teacher Rating Scale hyperactive-impulsive subscale T score of 65). Efficacy phase: 114 children completing the titration phase. Exclusions: previous stimulant treatment; intolerance to methylphenidate; Children’s Global Assessment Scale impairment score 
50; different primary caregiver over past 6 months; Full Scale IQ score equivalent of 
70 on the Differential Ability Scales; less than 2 days/week in school; adjustment disorder; psychosis; suicidal; other psychiatric disorder requiring medication; other medical condition; parental history of bipolar disorder; or cocaine or stimulant abuse
CMRI/Shaun Walters Professor of Pediatrics, OU Child Study Center,
Oklahoma City, Oklahoma, USA
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